Why do people with fibromyalgia have an itchy skin?

People with fibromyalgia also deal with a less known symptom, skin rash or itchy skin. At first, not many will concern the itching of the skin to chronic pain disorder. However, rashes and itching can indicate different medical conditions related to fibromyalgia.


Several groups of researchers have conducted several separate studies to find out the relationship between fibromyalgia and itchy skin. Here are some theories behind the rash and itching of fibromyalgia.
An immunological reaction under the skin
Skin itching or rash may occur due to an immune reaction just below the surface of the skin. According to early investigations conducted by Dr. X Caro of the Southern California Fibromyalgia Therapy Center, in Northbridge, California, the immunoreactive proteins found beneath the surface of the skin in fibromyalgia patients are responsible for the sensitivity of the skin These proteins are believed to have escaped through generally larger pores in blood vessels and are seen as foreign substances in skin tissues. The body’s immunity reacts to attack these proteins just below the skin and cause the appearance of a rash or itching.

Result of image for fibrous itchy skin rashes

Microcirculation anomalies
skin The rash and irritation can also be the result of a deformation of the microcirculation under the skin. The research conducted by Dr. Sprott H, found evidence of distorted structure and function of the microcirculation, including capillaries and blood vessels, under the skin in patients with fibromyalgia particularly close to tender points. These abnormalities disturb the blood flow to the skin and can be responsible for skin irritation, skin rashes and skin sensations.
Increased mast cells and neurological reaction in the skin
A Swedish study found that patients with fibromyalgia have significantly higher mast cells on their skin than controls. Mast cells are components of the immune system and contain chemicals such as histamines and cytokines. Once released, these chemicals cause irritation in the surrounding skin tissues. This usually occurs during a neurological response.
A misinterpretation of pain from the central nervous system
Sometimes itching and rash may be due to misinterpretation of pain signals. Fibromyalgia has been linked to a defective central nervous system that may seem to process pain as accurately as normal people do. Subcutaneous receptors send sensory messages to the brain that are misinterpreted as itching.

How to treat the rash and itching of fibromyalgia
For the treatment of rashes, itching or burning sensation, over-the-counter skin cream, lotions and moisturizers can help soothe the skin. Doctors can also prescribe skin creams and lotions for the most serious eruption.
Sources:
Dear XJ. Immunofluorescence studies of the skin in primary fibrosome syndrome. Am J Med. 1986, 29 September; 81 (3A): 43-9.
Dear XJ, Wolfe F, Johnston WH, Smith A L. A controlled and blinded study of immunoreactive deposition at the dermo-epidermal junction of patients with primary fibrosome syndrome. J Rheumatol. 1986 Dec; 13 (6): 1086-92.
Dear XJ, Winter E F. Evidence of abnormal density of epidermal nerve fibers in fibromyalgia: clinical and immunological implications. Rheumatoid arthritis 2014 lug; 66 (7): 1945-54.
Sprott H et al. Abnormal microcirculation and skin temperature over the delicate points in fibromyalgia patients. Rheumatology (Oxford). 2000 August; 39 (8): 917-21.
Sprott H et al. Microcirculation abnormalities in patients with fibromyalgia, measured by capillary microscopy and laser flowmetry. Arthritis Res Ther. 2005; 7 (2): R209-16. Epub 2004 10 December.
Eneström S, Bengtsson A, Frödin T. Dermal IgG and breast augmentation in patients with relevant results for fibromyalgia or epiphenomena? Scand J Rheumatol. 1997; 26 (4): 308-13.
White I et al. Abnormal overexpression of mast cells in skin biopsies of patients with fibromyalgia. Clin Rheumatol. 2010 December; 29 (12): 1403-12

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